Real Madrid will play host to Barcelona on March 2, for the Copa del Rey first leg tie.
The Los Blancos will be without some of its key players for this El Clasico tie, as the trio of David Alaba, Ferland Mendy and Rodrygo will be unavailable for this game.
Rodrygo and Alaba got off injured in the Champions League game against Liverpool on Tuesday.
Barcelona however will be without Pedri and Ousmane Dembele.
Meanwhile, Carlo Ancelotti is expected to replace the absent trio with Nacho, Eduardo Camavinga and Federico Valverde respectively.
The second leg will be played at Camp Nou in April.